Environmental exposures and mutational patterns of cancer genomes

The etiology of most human cancers is unknown. Genetic inheritance and environmental factors are thought to have major roles, and for some types of cancer, exposure to carcinogens is a proven mechanism leading to tumorigenesis. Sequencing of entire cancer genomes has not only begun to provide clues regarding functionally relevant mutations, but has also paved the way towards understanding the initial exposures leading to DNA damage, repair and eventually to mutation of specific sequences within a cancer genome. Two recent studies of melanoma and small cell lung cancer exemplify what type of information can be gained from cancer genome sequencing

Ideal Bose gas in fractal dimensions and superfluid 4^4He in porous media

Physical properties of ideal Bose gas with the fractal dimensionality between D=2 and D=3 are theoretically investigated. Calculation shows that the characteristic features of the specific heat and the superfluid density of ideal Bose gas in fractal dimensions are strikingly similar to those of superfluid Helium-4 in porous media. This result indicates that the geometrical factor is dominant over mutual interactions in determining physical properties of Helium-4 in porous media.Comment: 13 pages, 6 figure

Numerical study of multilayer adsorption on fractal surfaces

We report a numerical study of van der Waals adsoprtion and capillary condensation effects on self-similar fractal surfaces. An assembly of uncoupled spherical pores with a power-law distributin of radii is used to model fractal surfaces with adjustable dimensions. We find that the commonly used fractal Frankel-Halsey-Hill equation systematically fails to give the correct dimension due to crossover effects, consistent with the findings of recent experiments. The effects of pore coupling and curvature dependent surface tension were also studied.Comment: 11 pages, 3 figure

Simulation of anyons with tensor network algorithms

Interacting systems of anyons pose a unique challenge to condensed matter simulations due to their non-trivial exchange statistics. These systems are of great interest as they have the potential for robust universal quantum computation, but numerical tools for studying them are as yet limited. We show how existing tensor network algorithms may be adapted for use with systems of anyons, and demonstrate this process for the 1-D Multi-scale Entanglement Renormalisation Ansatz (MERA). We apply the MERA to infinite chains of interacting Fibonacci anyons, computing their scaling dimensions and local scaling operators. The scaling dimensions obtained are seen to be in agreement with conformal field theory. The techniques developed are applicable to any tensor network algorithm, and the ability to adapt these ansaetze for use on anyonic systems opens the door for numerical simulation of large systems of free and interacting anyons in one and two dimensions.Comment: Fixed typos, matches published version. 16 pages, 21 figures, 4 tables, RevTeX 4-1. For a related work, see arXiv:1006.247

Entanglement renormalization, scale invariance, and quantum criticality

The use of entanglement renormalization in the presence of scale invariance is investigated. We explain how to compute an accurate approximation of the critical ground state of a lattice model, and how to evaluate local observables, correlators and critical exponents. Our results unveil a precise connection between the multi-scale entanglement renormalization ansatz (MERA) and conformal field theory (CFT). Given a critical Hamiltonian on the lattice, this connection can be exploited to extract most of the conformal data of the CFT that describes the model in the continuum limit.Comment: 4 pages, 3 figures, RevTeX 4. Revised for greater clarit

Boundary quantum critical phenomena with entanglement renormalization

We extend the formalism of entanglement renormalization to the study of boundary critical phenomena. The multi-scale entanglement renormalization ansatz (MERA), in its scale invariant version, offers a very compact approximation to quantum critical ground states. Here we show that, by adding a boundary to the scale invariant MERA, an accurate approximation to the critical ground state of an infinite chain with a boundary is obtained, from which one can extract boundary scaling operators and their scaling dimensions. Our construction, valid for arbitrary critical systems, produces an effective chain with explicit separation of energy scales that relates to Wilson's RG formulation of the Kondo problem. We test the approach by studying the quantum critical Ising model with free and fixed boundary conditions.Comment: 8 pages, 12 figures, for a related work see arXiv:0912.289

First order wetting of rough substrates and quantum unbinding

Replica and functional renormalization group methods show that, with short range substrate forces or in strong fluctuation regimes, wetting of a self-affine rough wall in 2D turns first-order as soon as the wall roughness exponent exceeds the anisotropy index of bulk interface fluctuations. Different thresholds apply with long range forces in mean field regimes. For bond-disordered bulk, fixed point stability suggests similar results, which ultimately rely on basic properties of quantum bound states with asymptotically power-law repulsive potentials.Comment: 11 pages, 1 figur

Coherent control for the spherical symmetric box potential in short and intensive XUV laser fields

Coherent control calculations are presented for a spherically symmetric box potential for non-resonant two photon transition probabilities. With the help of a genetic algorithm (GA) the population of the excited states are maximized and minimized. The external driving field is a superposition of three intensive extreme ultraviolet (XUV) linearly polarized laser pulses with different frequencies in the femtosecond duration range. We solved the quantum mechanical problem within the dipole approximation. Our investigation clearly shows that the dynamics of the electron current has a strong correlation with the optimized and neutralizing pulse shape.Comment: 11 Pages 3 Figure